Lethal midline granuloma is a rare disease of unknown. etiology characterized by ulcerative, necrotic lesion of the upper respiratory tract, progressive pulmonary and renal involvement and death in a period four to five months.
Diagnosis could be made by biopsy of upper respiratory tract in early stage and, needle biopsy of kidney in a late, and was confirmed often at autopsy.
In regard to treatment, recently, long-term and massive administration of corticosteroid, small dosage of radiation, chemotherapy could be tried, however, not stopped progression.
The authors, recently have observed 3 cases (finale,33 yrs. 36 yrs. 40 yrs.) of lethal midline granuloma which was confirmed ass pathologically. Under the treatment of long term, massive administration of prednisolone, gamma-globulin injection, tubercin-C vaccination, a little improvement of disease was made.
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